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Article

NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase α and its implication in breast cancer cell proliferation.

Journal of cellular and molecular medicine - 1 Sept 2018

Tran Mai Hoang, Seo Eunjeong, Min Soohong, Nguyen Quynh-Anh T, Choi Juyong, Lee Uk-Jin, Hong Soon-Sun, Kang Hyuk, Mansukhani Alka, Jou Ilo, Lee Sang Yoon

Abstract excerpt

Phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family members generate phosphatidylinositol 4,5-bisphosphate (PIP2), a critical lipid regulator of diverse physiological processes. The PIP5K-dependent PIP2 generation can also act upstream of the oncogenic phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Many studies have demonstrated various mechanisms of spatiotemporal regulation of PIP5K catalytic activity....

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Source

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Identifiers

PMID: 29851245
DOI: 10.1111/jcmm.13689
PMCID: PMC6111810

Genes

NEDD4
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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