Identification and Verification of Cdk5 Phosphorylated Deubiquitinating Enzyme BRCC3

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>It is known that the expression of the deubiquitinating enzyme BRCA1-BRCA2-containing complex subunit 3(BRCC3) is increased, as well as Cyclin-dependent protein kinase 5(Cdk5) in Parkinson’s Disease(PD), and both of them to be involved in neuroinflammatory response. But the regulatory mechanism of Cdk5 on the post-translational modification of BRCC3 remains uncl...

Topics

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• Alzheimer Disease
• BRCA1 Protein
• Cancer-related Molecular Pathways
• Molecular Dynamics Simulation
• Parkinson Disease
• Peptidase Inhibition and Analysis
• Protein Domains
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

493a5dbd-4dcd-5107-9b68-72b3d9beced0

DOI

10.21203/rs.3.rs-444296/v1