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Article

The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.

The Journal of biological chemistry - 14 Feb 2014

Wang Hua, Chen Yue, Lin Ping, Li Lei, Zhou Guisheng, Liu Guangchao, Logsdon Craig, Jin Jianping, Abbruzzese James L, Tan Tse-Hua, Wang Huamin

Abstract excerpt

HPK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in >95% pancreatic cancer through proteasome-mediated degradation. However, the mechanism of HPK1 loss has not been defined. The aims of this study are to identify the ubiquitin ligase and to examine the mechanisms that targets HPK1 degradation. We found that the CUL7/Fbxw8 ubiquitin ligase targeted HPK1 for degradation via the 26 S...

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Source

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Identifiers

PMID: 24362026
DOI: 10.1074/jbc.M113.520106
PMCID: PMC3924268

Genes

CUL7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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