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Article

USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5

17 Oct 2019

Abstract excerpt

The Krüppel-like factor 5 (KLF5) transcription factor is highly expressed in basal type breast cancer and promotes breast cancer cell proliferation, survival, migration, and tumorigenesis. KLF5 protein stability is regulated by ubiquitination. In this study, ubiquitin-specific protease 3 (USP3) was identified as a new KLF5 deubiquitinase by genome-wide siRNA library screening. We demonstrated that USP3 interacts...

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PMID: 31624151
DOI: 10.1074/jbc.ra119.009102

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