Article
The C-terminus of ribosomal protein uS4 contributes to small ribosomal subunit biogenesis and the fidelity of translation.
Biochimie - 1 Jul 2017
Kamath Divya, Allgeyer Benjamin B, Gregory Steven T, Bielski Margaret C, Roelofsz David M, Sabapathypillai Sharon L, Vaid Nikhil, O'Connor Michael
Abstract excerpt
Ribosomal protein uS4 is an essential ribosomal component involved in multiple functions, including mRNA decoding. Structural analyses indicate that during decoding, the interface between the C-terminus of uS4 and protein uS5 is disrupted and in agreement with this, C-terminal uS4 truncation mutants are readily isolated on the basis of their increased miscoding phenotypes. The same mutants can also display...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.