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Article

Hypermethylation of TRIM59 and KLF14 Influences Cell Death Signaling in Familial Alzheimer’s Disease

1 Jan 2018

Abstract excerpt

Epigenetic mechanisms play an important role in the development and progression of various neurodegenerative diseases. Abnormal methylation of numerous genes responsible for regulation of transcription, DNA replication, and apoptosis has been linked to Alzheimer’s disease (AD) pathology. We have recently performed whole transcriptome profiling of familial early‐onset Alzheimer’s disease (fEOAD) patient‐derived...

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PMID: 29849909
DOI: 10.1155/2018/6918797

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