BECN1 F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner

Abstract excerpt

Autophagy is necessary for lifespan extension in multiple model organisms and autophagy dysfunction impacts age-related phenotypes and diseases. Introduction of an F121A mutation into the essential autophagy protein BECN1 constitutively increases basal autophagy in young mice and reduces cardiac and renal age-related changes in longer-lived Becn1 F121A mutant mice. However, both autophagic and lysosomal activity...

Topics

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• Aging
• Autophagy
• Autophagy in Disease and Therapy
• Beclin-1
• Mice
• Muscular Atrophy
• Mutation
• Phenotype

Identifiers and source

Literature Corpus work

f04c34d1-304f-546d-8e3d-0e56afdc2a82

DOI

10.1101/2022.01.12.475960