BECN1F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner.

Abstract excerpt

Macroautophagy/autophagy is necessary for lifespan extension in multiple model organisms and autophagy dysfunction impacts age-related phenotypes and diseases. Introduction of an F121A mutation into the essential autophagy protein BECN1 constitutively increases basal autophagy in young mice and reduces cardiac and renal age-related changes in longer lived Becn1F121A mutant mice. However, both autophagic and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aging
• Share to Autophagy
• Share to Autophagy in Disease and Therapy