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Article

Genotype to phenotype mapping still needs underpinning by research in metabolism and enzymology.

Bioscience reports - 29 Jun 2018

Fell David A

Abstract excerpt

The article 'Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function' by Niehaus et al. published in this issue illustrates a number of the problems that still arise when attempting to translate genotypes to phenotypes, such as for interpreting mutant phenotypes or building genome-scale metabolic models. In this case, the mutation concerned appears to map to an enzyme in one of...

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PMID: 29848765
DOI: 10.1042/BSR20180520
PMCID: PMC6013700

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