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Article

Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.

Bioscience reports - 29 Jun 2018

Niehaus Thomas D, Elbadawi-Sidhu Mona, Huang Lili, Prunetti Laurence, Gregory Jesse F, de Crécy-Lagard Valérie, Fiehn Oliver, Hanson Andrew D

Abstract excerpt

NAD(P)H-hydrate epimerase (EC 5.1.99.6) is known to help repair NAD(P)H hydrates (NAD(P)HX), which are damage products existing as R and S epimers. The S epimer is reconverted to NAD(P)H by a dehydratase; the epimerase facilitates epimer interconversion. Epimerase deficiency in humans causes a lethal disorder attributed to NADHX accumulation. However, bioinformatic evidence suggest caution about this attribution...

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PMID: 29654173
DOI: 10.1042/BSR20180223
PMCID: PMC5938422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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