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Characterizing Proteins of Unknown Function: Orphan Cytochrome P450 Enzymes as a Paradigm

1 Jun 2010

Abstract excerpt

With the rapid completion of genomic sequences of organisms today, we have far more gene products than functions we can ascribe. A number of experimental strategies have been developed and applied, both in vitro and in vivo, to put functions to these orphan proteins. The "deorphanization" of human and Streptomyces cytochrome P450 enzymes is considered quite important for pharmacology, with ramifications for the...

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PMID: 20539034
DOI: 10.1124/mi.10.3.6

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