Article

Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results

2023-03-24

Abstract excerpt

<h4>SUMMARY</h4> Studies combining metabolomics and genetics, known as metabolite genome-wide association studies (mGWAS), have provided valuable insights into our understanding of the genetic control of metabolite levels. However, the biological interpretation of these associations remains challenging due to a lack of existing tools to annotate mGWAS gene-metabolite pairs beyond the use of conservative statistic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8524a61-9626-574f-bf97-982b783f4838
DOI: 10.1101/2023.03.22.533869

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies resultsDOI 10.1101/2023.03.22.533869Read

Exploring the Genetic Landscape of Metabolic Phenotypes with MetaboSignal.Semantic proximity Read

datadrivenhypothesis.org: A resource for metabolic gene discovery through integrated pathway co-essentiality mappingSemantic proximity Read

Prioritizing disease-causing metabolic genes by integrating metabolomics with whole exome sequencing dataSemantic proximity Read

GEMCAT – A new algorithm for gene expression-based prediction of metabolic alterationsSemantic proximity Read

Mapping metabolic coevolution identifies c11orf54 as the missing pentose pathway decarboxylase.Semantic proximity Read

Recoupled-STOCSY-based co-expression network analysis to extract phenotype-driven metabolite modules in NMR-based metabolomics dataset.Semantic proximity Read

A network-based approach for predicting key enzymes explaining metabolite abundance alterations in a disease phenotype.Semantic proximity Read

Metabolome Based Reaction Graphs of M. tuberculosis and M. leprae: A Comparative Network AnalysisSemantic proximity Read

Simulating Metabolic Pathways to Enhance Interpretations of Metabolome Genome-Wide Association StudiesSemantic proximity Read

EHMN 2026: A Thermodynamically Refined, SBML-Standardised Human Metabolic Network for Genome-Scale Analysis and QSP IntegrationSemantic proximity Read

Predicting the Pathway Involvement of Compounds Annotated in the Reactome Knowledge-baseSemantic proximity Read

Pathway analysis in metabolomics: pitfalls and best practice for the use of over-representation analysisSemantic proximity Read