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Article

Requirements for NuMA in maintenance and establishment of mammalian spindle poles.

The Journal of cell biology - 9 Mar 2009

Silk Alain D, Holland Andrew J, Cleveland Don W

Abstract excerpt

Microtubules of the mitotic spindle in mammalian somatic cells are focused at spindle poles, a process thought to include direct capture by astral microtubules of kinetochores and/or noncentrosomally nucleated microtubule bundles. By construction and analysis of a conditional loss of mitotic function allele of the nuclear mitotic apparatus (NuMA) protein in mice and cultured primary cells, we demonstrate that...

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Identifiers

PMID: 19255246
DOI: 10.1083/jcb.200810091
PMCID: PMC2686415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirements for NuMA in maintenance and establishment of mammalian spindle poles.PMID 19255246Read ↗

NuMA is required for proper spindle assembly and chromosome alignment in prometaphaseSemantic proximity Read ↗

Mechanism of spindle pole organization and instability in human oocytesSemantic proximity Read ↗

Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble.Semantic proximity Read ↗

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.Semantic proximity Read ↗

Optogenetic reconstitution reveals that Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensembleSemantic proximity Read ↗

Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.Semantic proximity Read ↗

NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle polesSemantic proximity Read ↗

Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis.Semantic proximity Read ↗

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle lengthSemantic proximity Read ↗

Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis.Semantic proximity Read ↗

Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts.Semantic proximity Read ↗

Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle.Semantic proximity Read ↗

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