Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.

doi:10.1167/iovs.17-23536

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Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.

Investigative ophthalmology & visual science - 1 May 2018

Fan Bao Jian, Chen Xueli, Sondhi Nisha, Sharmila P Ferdinamarie, Soumittra Nagasamy, Sripriya Sarangapani, Sacikala Srinivasan, Asokan Rashima, Friedman David S, Pasquale Louis R, Gao X Raymond, Vijaya Lingam, Cooke Bailey Jessica, Vitart Veronique, MacGregor Stuart, Hammond Christopher J, Khor Chiea Chuen, Haines Jonathan L, George Ronnie, Wiggs Janey L

Abstract excerpt

Purpose: To identify genetic risk factors contributing to central corneal thickness (CCT) in individuals from South India, a population with a high prevalence of ocular disorders. Methods: One hundred ninety-five individuals from 15 large South Indian pedigrees were genotyped using the Omni2.5 bead array. Family-based association for CCT was conducted using the score test in MERLIN. Results: Genome-wide...

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PMID: 29847655
DOI: 10.1167/iovs.17-23536
PMCID: PMC5961220

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