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Article

Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness.

Human genetics - 1 Nov 2012

Hoehn René, Zeller Tanja, Verhoeven Virginie J M, Grus Franz, Adler Max, Wolfs Roger C, Uitterlinden André G, Castagne Raphaële, Schillert Arne, Klaver Caroline C W, Pfeiffer Norbert, Mirshahi Alireza

Abstract excerpt

Central corneal thickness (CCT) has become an endophenotype of major interest for the genetically complex disorder glaucoma. CCT has a high heritability, and thin CCT is an independent risk factor for the diagnosis and progression of open-angle glaucoma. Genome-wide association studies thus provide genetic loci associated with CCT and potentially related to open-angle glaucoma. The distribution of CCT and...

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PMID: 22814818
DOI: 10.1007/s00439-012-1201-3

Genes

RXRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness.PMID 22814818Read ↗

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