Article
Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations.
Human molecular genetics - 15 Jan 2012
Cornes Belinda K, Khor Chiea Chuen, Nongpiur Monisha E, Xu Liang, Tay Wan-Ting, Zheng Yingfeng, Lavanya Raghavan, Li Yang, Wu Renyi, Sim Xueling, Wang Ya-Xing, Chen Peng, Teo Yik Ying, Chia Kee-Seng, Seielstad Mark, Liu Jianjun, Hibberd Martin L, Cheng Ching-Yu, Saw Seang-Mei, Tai E-Shyong, Jonas Jost B, Vithana Eranga N, Wong Tien Y, Aung Tin
Abstract excerpt
Central corneal thickness (CCT) is a highly heritable trait. Genes that significantly influence CCT can be candidate genes for common disorders in which CCT has been implicated, such as primary open-angle glaucoma (POAG) and keratoconus. Because the genetic factors controlling CCT in different Asian populations are unclear, we have built on previous work conducted on Singaporean Indians and Malays and extended...
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