Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness.

Communications biology - 11 Jun 2020

Choquet Hélène, Melles Ronald B, Yin Jie, Hoffmann Thomas J, Thai Khanh K, Kvale Mark N, Banda Yambazi, Hardcastle Alison J, Tuft Stephen J, Glymour M Maria, Schaefer Catherine, Risch Neil, Nair K Saidas, Hysi Pirro G, Jorgenson Eric

Abstract excerpt

Central corneal thickness (CCT) is one of the most heritable human traits, with broad-sense heritability estimates ranging between 0.68 to 0.95. Despite the high heritability and numerous previous association studies, only 8.5% of CCT variance is currently explained. Here, we report the results of a multiethnic meta-analysis of available genome-wide association studies in which we find association between CCT and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Cornea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corneal Diseases

Share to Ethnicity

Share to Genetic Loci

Share to Glaucoma

Share to Mendelian Randomization Analysis

Share to Meta-Analysis as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 32528159
DOI: 10.1038/s42003-020-1037-7
PMCID: PMC7289804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness.PMID 32528159Read ↗

The genetics of central corneal thicknessSemantic proximity Read ↗

Genome-wide discovery reveals 30 loci for choroidal thickness and uncovers potential causal links with angle-closure glaucomaSemantic proximity Read ↗

Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations.Semantic proximity Read ↗

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.Semantic proximity Read ↗

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.Semantic proximity Read ↗

Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomisation mediation analysis.Semantic proximity Read ↗

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.Semantic proximity Read ↗

Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomization mediation analysisSemantic proximity Read ↗

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.Semantic proximity Read ↗

A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries.Semantic proximity Read ↗

Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.Semantic proximity Read ↗

Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.