Article
WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness.
Human molecular genetics - 1 Sept 2015
Cuellar-Partida Gabriel, Springelkamp Henriët, Lucas Sionne E M, Yazar Seyhan, Hewitt Alex W, Iglesias Adriana I, Montgomery Grant W, Martin Nicholas G, Pennell Craig E, van Leeuwen Elisabeth M, Verhoeven Virginie J M, Hofman Albert, Uitterlinden André G, Ramdas Wishal D, Wolfs Roger C W, Vingerling Johannes R, Brown Matthew A, Mills Richard A, Craig Jamie E, Klaver Caroline C W, van Duijn Cornelia M, Burdon Kathryn P, MacGregor Stuart, Mackey David A
Abstract excerpt
Keratoconus is a degenerative eye condition which results from thinning of the cornea and causes vision distortion. Treatments such as ultraviolet (UV) cross-linking have proved effective for management of keratoconus when performed in early stages of the disease. The central corneal thickness (CCT) is a highly heritable endophenotype of keratoconus, and it is estimated that up to 95% of its phenotypic variance...
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