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Article

Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation.

Biomechanics and modeling in mechanobiology - 1 Dec 2011

Maul Timothy M, Chew Douglas W, Nieponice Alejandro, Vorp David A

Abstract excerpt

Mesenchymal stem cell (MSC) therapy has demonstrated applications in vascular regenerative medicine. Although blood vessels exist in a mechanically dynamic environment, there has been no rigorous, systematic analysis of mechanical stimulation on stem cell differentiation. We hypothesize that mechanical stimuli, relevant to the vasculature, can differentiate MSCs toward smooth muscle (SMCs) and endothelial cells...

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Identifiers

PMID: 21253809
DOI: 10.1007/s10237-010-0285-8
PMCID: PMC3208754

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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