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Article

Protective role for caspase-11 during acute experimental murine colitis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015

Oficjalska Katarzyna, Raverdeau Mathilde, Aviello Gabriella, Wade Siobhan C, Hickey Ana, Sheehan Katherine M, Corr Sinead C, Kay Elaine W, O'Neill Luke A, Mills Kingston H G, Creagh Emma M

Abstract excerpt

Activation of the noncanonical inflammasome, mediated by caspase-11, serves as an additional pathway for the production of the proinflammatory cytokines IL-1β and IL-18. Noncanonical inflammasome activity occurs during host defense against Gram-negative bacteria and in models of acute septic shock. We propose that the noncanonical inflammasome is activated in mice during acute intestinal inflammation elicited by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25548224
DOI: 10.4049/jimmunol.1400501
PMCID: PMC4298125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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