Article
The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis.
European journal of immunology - 1 Aug 2011
van de Veerdonk Frank L, Joosten Leo A B, Shaw Patrick J, Smeekens Sanne P, Malireddi R K Subbarao, van der Meer Jos W M, Kullberg Bart-Jan, Netea Mihai G, Kanneganti Thirumala-Devi
Abstract excerpt
The Nlrp3 inflammasome has been proposed to play an important role in antifungal host defense. However, studies exploring the role of the inflammasome in antifungal host defense have been limited to the direct effects on IL-1β processing. Although IL-1β has important direct effects on the innate immune response, important effects of the caspase-1-dependent cytokines IL-1β and IL-18 are exerted on the initiation...
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