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TLR2-FADS1-cPLA2-arachidonic acid axis drives necroptosis to restrict zoonotic Cryptosporidium parvum infection and mitigate intestinal injury

2025-06-13

Abstract excerpt

<title>Abstract</title> <p>Cryptosporidiosis is a globally prevalent diarrheal disease caused by Cryptosporidium parvum (C. parvum), yet effective therapies remain lacking. Here, we uncover a host-protective mechanism wherein C. parvum infection activated necroptosis via the TLR2-FADS1-cPLA2-arachidonic acid axis to limit parasitic proliferation and intestinal pathology. Through integrated transcriptomic and meta...

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Literature Corpus work
3fc7dc6d-1425-5457-931f-130c6e373f85
DOI
10.21203/rs.3.rs-6769819/v1
Open publication

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TLR2-FADS1-cPLA2-arachidonic acid axis drives necroptosis to restrict zoonotic Cryptosporidium parvum infection and mitigate intestinal injuryDOI 10.21203/rs.3.rs-6769819/v1
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