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Identification of nonsense variants in the genomes of 15 Murciano-Granadina bucks and analysis of their segregation in parent-offspring trios.

Journal of dairy science - 1 Dec 2024

Wang Ke, Luigi-Sierra María Gracia, Castelló Anna, Figueiredo-Cardoso Taina, Mercadé Anna, Martínez Amparo, Delgado Juan Vicente, Álvarez Javier Fernández, Noce Antonia, Wang Mingjing, Jordana Jordi, Amills Marcel

Abstract excerpt

Nonsense variants can inactivate gene function by causing the synthesis of truncated proteins or by inducing nonsense mediated decay of messenger RNAs. The occurrence of such variants in the genomes of livestock species is modulated by multiple demographic and selective factors. Even though nonsense variants can have causal effects on embryo lethality, abortions, and disease, their genomic distribution and...

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PMID: 39218071
DOI: 10.3168/jds.2024-24952

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