Article
Progression and enhancement of metastatic potential after exposure of tumor cells to chemotherapeutic agents.
Cancer research - 1 Apr 2001
De Larco J E, Wuertz B R, Manivel J C, Furcht L T
Abstract excerpt
Data presented in this report indicate short-term in vitro treatment of nonmetastatic MCF-7 breast carcinoma cells with the chemotherapeutic agents-, Adriamycin and/or 5-fluoro-2'-deoxyuridine (FUdR), induced changes in the expressed phenotype. Cells treated sequentially with Adriamycin and FUdR expressed a metastatic phenotype. The results also show short-term exposure of MCF-7 cells to either Adriamycin or FUdR...
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