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Article

The CCL5/CCR5 Axis Promotes Vascular Smooth Muscle Cell Proliferation and Atherogenic Phenotype Switching.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2018

Lin Chin-Sheng, Hsieh Po-Shiuan, Hwang Ling-Ling, Lee Yen-Hsien, Tsai Shih-Hung, Tu Yun-Chin, Hung Yao-Wen, Liu Cheng-Che, Chuang Yi-Ping, Liao Min-Tser, Chien Shu, Tsai Min-Chien

Abstract excerpt

BACKGROUND/AIMS: Hyperlipidemia induces dysfunction in the smooth muscle cells (SMCs) of the blood vessels, and the vascular remodeling that ensues is a key proatherogenic factor contributing to cardiovascular events. Chemokines and chemokine receptors play crucial roles in vascular remodeling. Here, we examined whether the hyperlipidemia-derived chemokine CCL5 and its receptor CCR5 influence vascular SMC...

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Share to Atherosclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Mitogen-Activated Protein Kinases

Share to Muscle, Smooth, Vascular

Share to Osteopontin

Share to Proliferating Cell Nuclear Antigen

Share to Receptors, CCR5

Source

Identifiers

PMID: 29794461
DOI: 10.1159/000490024

Genes

CCL5
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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