Article
Resveratrol inhibits phenotype modulation by platelet derived growth factor-bb in rat aortic smooth muscle cells.
Oxidative medicine and cellular longevity - 1 Jan 2014
Lee Mi Hee, Kwon Byeong-Ju, Seo Hyok Jin, Yoo Kyeong Eun, Kim Min Sung, Koo Min-Ah, Park Jong-Chul
Abstract excerpt
Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of platelet derived growth factor-bb (PDGF-bb) in rat aortic vascular smooth muscle cells (RAOSMCs)....
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