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Article

AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2024

Sun Jingwen, Shao Yuting, Pei Lele, Zhu Qingyu, Yu Xiaoqiang, Yao Wenjuan

Abstract excerpt

The roles and mechanisms of A-kinase anchoring protein 1 (AKAP1) in vascular smooth muscle cell (VSMC) phenotypic modulation and neointima formation are currently unknown. AKAP1 is a mitochondrial PKA-anchored protein and maintains mitochondrial homeostasis. This study aimed to investigate how AKAP1/PKA signaling plays a protective role in inhibiting VSMC phenotypic transformation and neointima formation by...

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Identifiers

PMID: 38850669
DOI: 10.1016/j.biopha.2024.116858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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