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Article

IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn's Disease.

Inflammatory bowel diseases - 15 Sept 2018

Simon Tracey G, Van Der Sloot Kimberley W J, Chin Samantha B, Joshi Amit D, Lochhead Paul, Ananthakrishnan Ashwin N, Xavier Ramnik, Chung Raymond T, Khalili Hamed

Abstract excerpt

Background: Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized comorbidity in Crohn's disease (CD), but the mechanisms are poorly understood. Autophagy is a highly conserved process regulating innate immunity that contributes to CD susceptibility. Emerging data suggest that variants in the autophagy-governing IRGM gene may contribute to the accumulation of visceral adipose tissue (VAT) and...

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Identifiers

PMID: 29788077
DOI: 10.1093/ibd/izy128
PMCID: PMC6230523

Genes

IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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