Article
Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.
Pigment cell & melanoma research - 1 Nov 2018
Tharmarajah Grace, Eckhard Ulrich, Jain Fagun, Marino Giada, Prudova Anna, Urtatiz Oscar, Fuchs Helmut, de Angelis Martin H, Overall Christopher M, Van Raamsdonk Catherine D
Abstract excerpt
The mouse tail has an important role in the study of melanogenesis, because mouse tail skin can be used to model human skin pigmentation. To better understand the development of melanocytes in the mouse tail, we cloned two dominant ENU-generated mutations of the Adamts9 gene, Und3 and Und4, which cause an unpigmented ring of epidermis in the middle of the tail, but do not alter pigmentation in the rest of the...
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