Article
Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.
Development (Cambridge, England) - 1 Dec 2010
Enomoto Hiroyuki, Nelson Courtney M, Somerville Robert P T, Mielke Katrina, Dixon Laura J, Powell Kimerly, Apte Suneel S
Abstract excerpt
We have identified a role for two evolutionarily related, secreted metalloproteases of the ADAMTS family, ADAMTS20 and ADAMTS9, in palatogenesis. Adamts20 mutations cause the mouse white-spotting mutant belted (bt), whereas Adamts9 is essential for survival beyond 7.5 days gestation (E7.5). Functional overlap of Adamts9 with Adamts20 was identified using Adamts9(+/-);bt/bt mice, which have a fully penetrant cleft...
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