Article
A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.
Genesis (New York, N.Y. : 2000) - 1 Jul 2014
Dubail Johanne, Aramaki-Hattori Noriko, Bader Hannah L, Nelson Courtney M, Katebi Negin, Matuska Brittany, Olsen Bjorn R, Apte Suneel S
Abstract excerpt
ADAMTS9 is the most conserved member of a large family of secreted metalloproteases having diverse functions. Adamts9 null mice die before gastrulation, precluding investigations of its roles later in embryogenesis, in adult mice or disease models. We therefore generated a floxed Adamts9 allele to bypass embryonic lethality. In this mutant, unidirectional loxP sites flank exons 5-8, which encode the catalytic...
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