Article
CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA.
Frontiers in immunology - 1 Jan 2018
Martin Genevieve E, Pace Matthew, Thornhill John P, Phetsouphanh Chansavath, Meyerowitz Jodi, Gossez Morgane, Brown Helen, Olejniczak Natalia, Lwanga Julianne, Ramjee Gita, Kaleebu Pontiano, Porter Kholoud, Willberg Christian B, Klenerman Paul, Nwokolo Nneka, Fox Julie, Fidler Sarah, Frater John
Abstract excerpt
Efforts to both characterize and eradicate the HIV reservoir have been limited by the rarity of latently infected cells and the absence of a specific denoting biomarker. CD32a (FcγRIIa) has been proposed to be a marker for an enriched CD4 T cell HIV reservoir, but this finding remains controversial. Here, we explore the expression of CD32 on CD3+CD4+ cells in participants from two primary HIV infection studies...
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