Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation.

doi:10.1038/s41586-025-09893-0

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Article

Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation.

Nature - 1 Feb 2026

Gaebler Christian, Kor Samad, Allers Kristina, Perotti Michela, Mwangi David, Meixenberger Karolin, Hanke Kirsten, Trenkner Timo, Kraus Tom, Sha Yeqin, Arentowicz Carmen, Odidika Stanley, Grahn Nikolai, Scheck Rachel, Perkins Naomi, Pardons Marion, Igbokwe Vanessa, Corman Victor, Burmeister Thomas, Blau Olga, Sürücü Gülüstan, Pruß Axel, Schneider Christian G, Klausen Gerd, Sauter Jürgen, Klein Florian, Sander Leif E, Hofmann Jörg, Vuong Lam, Bullinger Lars, Penter Livius, Gruell Henning, Reeves Daniel B, Schommers Philipp, Hoelzemer Angelique, Obermeier Martin, Blau Igor W, Schneider Thomas, Penack Olaf

Abstract excerpt

HIV cure is exceptionally rare, with only six cases documented among the estimated 88 million individuals who have acquired HIV since the onset of the epidemic1-6. Successful cures, including that of the pioneering individual known as the Berlin patient, are limited to those who received allogeneic stem cell transplants (allo-SCTs) for haematological cancers. HIV resistance from stem cell donors with the rare...

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Identifiers

PMID: 41326734
DOI: 10.1038/s41586-025-09893-0
PMCID: PMC12916306

Genes

CCR5
SCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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