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Article

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology.

Molecular neurodegeneration - 18 May 2018

Pace Michael C, Xu Guilian, Fromholt Susan, Howard John, Giasson Benoit I, Lewis Jada, Borchelt David R

Abstract excerpt

BACKGROUND: Prior studies in C. elegans demonstrated that the expression of aggregation-prone polyglutamine proteins in muscle wall cells compromised the folding of co-expressed temperature-sensitive proteins, prompting interest in whether the accumulation of a misfolded protein in pathologic features of human neurodegenerative disease burdens cellular proteostatic machinery in a manner that impairs the folding...

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Identifiers

PMID: 29776378
DOI: 10.1186/s13024-018-0253-9
PMCID: PMC5960184

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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