Article

TMEM106B C-terminal fragments aggregate and drive neurodegenerative proteinopathy

2024-06-11

Abstract excerpt

Genetic variation in the lysosomal and transmembrane protein 106B (TMEM106B) modifies risk for a diverse range of neurodegenerative disorders, especially frontotemporal lobar degeneration (FTLD) with progranulin (PGRN) haplo-insufficiency, although the molecular mechanisms involved are not yet understood. Through advances in cryo-electron microscopy (cryo-EM), homotypic aggregates of the C-Terminal domain of TMEM1...

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Literature Corpus work: 3d327eb9-a6d4-5785-88b6-bad413cb165c
DOI: 10.1101/2024.06.11.598478

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