Variation in Interleukin 6 Receptor Gene Associates With Risk of Crohn's Disease and Ulcerative Colitis.

doi:10.1053/j.gastro.2018.05.022

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Article

Variation in Interleukin 6 Receptor Gene Associates With Risk of Crohn's Disease and Ulcerative Colitis.

Gastroenterology - 1 Aug 2018

Parisinos Constantinos A, Serghiou Stylianos, Katsoulis Michail, George Marc Jonathan, Patel Riyaz S, Hemingway Harry, Hingorani Aroon D

Abstract excerpt

Interleukin 6 (IL6) is an inflammatory cytokine; signaling via its receptor (IL6R) is believed to contribute to development of inflammatory bowel diseases (IBD). The single nucleotide polymorphism rs2228145 in IL6R associates with increased levels of soluble IL6R (s-IL6R), as well as reduced IL6R signaling and risk of inflammatory disorders; its effects are similar to those of a therapeutic monoclonal antibody...

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Identifiers

PMID: 29775600
DOI: 10.1053/j.gastro.2018.05.022
PMCID: PMC6083435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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