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Article

IL6 genetic variants haplotype is associated with susceptibility and disease activity but not with therapy response in patients with inflammatory bowel disease.

International journal of colorectal disease - 1 Feb 2021

Gonçalves Beatriz Piantoni, Flauzino Tamires, Inoue Cláudia Junko, de Paula Jaqueline Costa Castardo, Galvão Talita Cristina, de Alcantara Camila Cataldi, Miyazaki Paula Kikuchi, Rosa Lucilene, Westmore Silva, Lozovoy Marcell Alysson Batisti, Reiche Edna Maria Vissoci, Simão Andréa Name Colado

Abstract excerpt

PURPOSE: The aim of the present study was to evaluate the IL6 -174 G>C (rs1800795) and -572 G>C (rs1800796) genetic variants and their association with inflammatory bowel diseases (IBDs), disease activity, and response to TNF-α inhibitors. METHODS: The study included 178 patients with IBD and 224 healthy controls. Among the IBD patients, 66 of them were in use of TNF-α inhibitors therapy and were followed during...

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PMID: 33047210
DOI: 10.1007/s00384-020-03743-3

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