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Article

Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO‐dependent Stn1 telomere association

12 Jun 2014

Abstract excerpt

Elongation of the telomeric overhang by telomerase is counteracted by synthesis of the complementary strand by the CST complex, CTC1(Cdc13)/Stn1/Ten1. Interaction of budding yeast Stn1 with overhang‐binding Cdc13 is increased by Cdc13 SUMOylation. Human and fission yeast CST instead interact with overhang‐binding TPP1/POT1. We show that the fission yeast TPP1 ortholog, Tpz1, is SUMOylated. Tpz1 SUMOylation...

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Identifiers

PMID: 24925530
DOI: 10.15252/embr.201438919

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Related research

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Research trail→

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Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO‐dependent Stn1 telomere associationPMID 24925530Read ↗

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.Semantic proximity Read ↗

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Protection of telomeres by a conserved Stn1–Ten1 complexSemantic proximity Read ↗

Dysfunction of Telomeric Cdc13-Stn1-Ten1 Simultaneously Activates DNA Damage and Spindle Checkpoints.Semantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeresSemantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

Role of SUMO in the dynamics of telomere maintenance in fission yeast.Semantic proximity Read ↗

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.Semantic proximity Read ↗

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.Semantic proximity Read ↗

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

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