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Article

Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans.

The Journal of clinical endocrinology and metabolism - 1 Jul 2011

Peter Andreas, Stefan Norbert, Cegan Alexander, Walenta Mareike, Wagner Silvia, Königsrainer Alfred, Königsrainer Ingmar, Machicao Fausto, Schick Fritz, Häring Hans-Ulrich, Schleicher Erwin

Abstract excerpt

BACKGROUND/AIMS: Glucokinase (GCK) phosphorylates glucose to form glucose 6-phosphate and thereby regulates hepatic glucose disposal and activates hepatic lipogenesis. Hepatic GCK activity is regulated on the level of GCK mRNA expression and by the inhibitory glucokinase regulatory protein. In this study, we aimed to investigate the relation between GCK mRNA expression and markers of lipogenesis as well as liver...

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Source

Identifiers

PMID: 21490074
DOI: 10.1210/jc.2010-2017

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans.PMID 21490074Read ↗

Common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a meta-analysis.Semantic proximity Read ↗

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variantSemantic proximity Read ↗

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.Semantic proximity Read ↗

Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease.Semantic proximity Read ↗

Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.Semantic proximity Read ↗

Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.Semantic proximity Read ↗

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.Semantic proximity Read ↗

Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Non-alcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants.Semantic proximity Read ↗

Hepatic energy metabolism in a family with a glucokinase gene mutation and dysglycemia.Semantic proximity Read ↗

Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study.Semantic proximity Read ↗

Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.Semantic proximity Read ↗

GCKR polymorphism influences liver fat content in patients with type 2 diabetes.Semantic proximity Read ↗

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