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Article

Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis.

The Journal of biological chemistry - 6 Jul 2018

Ward Diane M, Chen Opal S, Li Liangtao, Kaplan Jerry, Bhuiyan Shah Alam, Natarajan Selvamuthu K, Bard Martin, Cox James E

Abstract excerpt

Ergosterol synthesis is essential for cellular growth and viability of the budding yeast Saccharomyces cerevisiae, and intracellular sterol distribution and homeostasis are therefore highly regulated in this species. Erg25 is an iron-containing C4-methyl sterol oxidase that contributes to the conversion of 4,4-dimethylzymosterol to zymosterol, a precursor of ergosterol. The ERG29 gene encodes an endoplasmic...

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Identifiers

PMID: 29773647
DOI: 10.1074/jbc.RA118.001781
PMCID: PMC6036212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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