Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.

Eukaryotic cell - 1 Jul 2008

Lavoie Hugo, Whiteway Malcolm

Abstract excerpt

Loss of the protein kinase Sch9p increases both the chronological life span (CLS) and the replicative life span (RLS) of Saccharomyces cerevisiae by mimicking calorie restriction, but the physiological consequences of SCH9 deletion are poorly understood. By transcriptional profiling of an sch9Delta mutant, we show that mitochondrial electron transport chain genes are upregulated. Accordingly, protein levels of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Binding Factor
Share to Electron Transport Chain Complex Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Microarray Analysis

Share to Mitochondrial Proteins

Share to Protein Serine-Threonine Kinases

Share to Saccharomyces cerevisiae Proteins

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 18469137
DOI: 10.1128/EC.00330-07
PMCID: PMC2446671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.PMID 18469137Read ↗

Extension of chronological life span in yeast by decreased TOR pathway signaling.Semantic proximity Read ↗

Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension.Semantic proximity Read ↗

Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.Semantic proximity Read ↗

Molecular Mechanisms of Genotype-Dependent Lifespan Variation Mediated by Caloric Restriction: Insight from Wild Yeast IsolatesSemantic proximity Read ↗

Mitochondrial Efficiency-Dependent Viability of Saccharomyces cerevisiae Mutants Carrying Individual Electron Transport Chain Component Deletions.Semantic proximity Read ↗

A novel NADH kinase is the mitochondrial source of NADPH in Saccharomyces cerevisiae.Semantic proximity Read ↗

Interplay among Gcn5, Sch9 and mitochondria during chronological aging of wine yeast is dependent on growth conditions.Semantic proximity Read ↗

Hap4 is not essential for activation of respiration at low specific growth rates in Saccharomyces cerevisiae.Semantic proximity Read ↗

Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant.Semantic proximity Read ↗

Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.Semantic proximity Read ↗

Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populations.Semantic proximity Read ↗

Tolerance to NADH/NAD <sup>+</sup> imbalance anticipates aging and anti-aging interventionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.