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Article

Salutary Effects of Overexpression of Rsm22, an Assembly Factor for the Mitochondrial Ribosome, on Frataxin/Yfh1 Depletion Phenotypes in Saccharomyces cerevisiae.

Biomolecules - 28 May 2025

Pandey Ashutosh K, Singh Pratibha, Pain Jayashree, Dancis Andrew, Pain Debkumar

Abstract excerpt

Frataxin is a component of the iron-sulfur (Fe-S) cluster assembly complex in mitochondria, and deficiency is associated with Friedreich ataxia (FA). The yeast homolog Yfh1 resembles and cross-complements with its human equivalent, and frataxin bypass scenarios are of particular interest because they may point to strategies for treating FA. Here, we describe frataxin/Yfh1 bypass by overexpression of Rsm22, an...

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Identifiers

PMID: 40563426
DOI: 10.3390/biom15060785
PMCID: PMC12191369

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Salutary Effects of Overexpression of Rsm22, an Assembly Factor for the Mitochondrial Ribosome, on Frataxin/Yfh1 Depletion Phenotypes in Saccharomyces cerevisiae.PMID 40563426Read ↗

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