Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia.

Haematologica - 1 Sept 2018

Geyh Stefanie, Rodríguez-Paredes Manuel, Jäger Paul, Koch Annemarie, Bormann Felix, Gutekunst Julian, Zilkens Christoph, Germing Ulrich, Kobbe Guido, Lyko Frank, Haas Rainer, Schroeder Thomas

Abstract excerpt

Mesenchymal stromal cells are involved in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia, but the underlying mechanisms are incompletely understood. To further characterize the pathological phenotype we performed RNA sequencing of mesenchymal stromal cells from patients with myelodysplastic syndromes and acute myeloid leukemia and found a specific molecular signature of genes commonly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Mesenchymal Stem Cells

Share to Myelodysplastic Syndromes

Share to Osteogenesis

Share to Pteridines

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 29773599
DOI: 10.3324/haematol.2017.186734
PMCID: PMC6119130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia.PMID 29773599Read ↗

Mesenchymal Stem Cells in Myelodysplastic Syndromes and Leukaemia MicroenvironmentSemantic proximity Read ↗

Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells.Semantic proximity Read ↗

Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy.Semantic proximity Read ↗

Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes.Semantic proximity Read ↗

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.Semantic proximity Read ↗

Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cellsSemantic proximity Read ↗

Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia.Semantic proximity Read ↗

Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programsSemantic proximity Read ↗

Impaired Proliferative Potential of Bone Marrow Mesenchymal Stromal Cells in Patients with Myelodysplastic Syndromes Is Associated with Abnormal WNT Signaling PathwaySemantic proximity Read ↗

STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromesSemantic proximity Read ↗

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesisSemantic proximity Read ↗

Oncodevelopmental plasticity of the skeleton in myeloid neoplasmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.