Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes

10 Feb 2025

Abstract excerpt

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) represent complex hematopoietic malignancies characterized by ineffective hematopoiesis and dysregulated myeloid differentiation. Recent research has underscored the critical role of aberrant STAT signaling pathways, particularly involving STAT3 and STAT5, in the pathogenesis of these disorders. Aberrant activation of STAT proteins has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cytokine Signaling Pathways and Interactions
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39933227
DOI: 10.1016/j.neo.2025.101137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromesPMID 39933227Read ↗

STAT signaling in the pathogenesis and treatment of myeloid malignanciesSemantic proximity Read ↗

Dissecting Out a Rare Mutation, STAT: Features of STAT3-Mutant Myeloid Neoplasms.Semantic proximity Read ↗

Integrated Clinical Genotype-Phenotype Characteristics of STAT3-Mutated Myeloid Neoplasms.Semantic proximity Read ↗

Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy.Semantic proximity Read ↗

STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemiaSemantic proximity Read ↗

Navigating the contested borders between myelodysplastic syndrome and acute myeloid leukemiaSemantic proximity Read ↗

Acute leukemia: a pediatric perspective.Semantic proximity Read ↗

Mesenchymal Stem Cells in Myelodysplastic Syndromes and Leukaemia MicroenvironmentSemantic proximity Read ↗

Roles of STAT3 in leukemia (Review)Semantic proximity Read ↗

Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic CorrelatesSemantic proximity Read ↗

JAK-STAT pathway in hematological malignancies: achievements, challenges and future perspectivesSemantic proximity Read ↗

JAK/STAT Pathways in Cytokine Signaling and Myeloproliferative Disorders: Approaches for Targeted TherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.