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Article

Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia.

Leukemia - 1 Mar 2016

Geyh S, Rodríguez-Paredes M, Jäger P, Khandanpour C, Cadeddu R-P, Gutekunst J, Wilk C M, Fenk R, Zilkens C, Hermsen D, Germing U, Kobbe G, Lyko F, Haas R, Schroeder T

Abstract excerpt

Hematopoietic insufficiency is the hallmark of acute myeloid leukemia (AML) and predisposes patients to life-threatening complications such as bleeding and infections. Addressing the contribution of mesenchymal stromal cells (MSC) to AML-induced hematopoietic failure we show that MSC from AML patients (n=64) exhibit significant growth deficiency and impaired osteogenic differentiation capacity. This was...

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PMID: 26601782
DOI: 10.1038/leu.2015.325

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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