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Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs

25 Apr 2016

Abstract excerpt

Myelodysplastic syndromes (MDS) have long been considered hematopoietic-cell autonomous disorders in which disease initiation and progression is exclusively driven by hematopoietic cell intrinsic genetic events. Recent experimental findings have challenged this view, implicating mesenchymal elements in the bone marrow microenvironment in disease pathogenesis. Specifically, genetic perturbation of mesenchymal...

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PMID: 27109510
DOI: 10.1038/leu.2016.91

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