R46L polymorphism in the PCSK9 gene: Relationship to lipid levels, subclinical vascular disease, and erectile dysfunction.

doi:10.1016/j.jacl.2018.04.004

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Article

R46L polymorphism in the PCSK9 gene: Relationship to lipid levels, subclinical vascular disease, and erectile dysfunction.

Journal of clinical lipidology - 1 Jan 2000

Mostaza Jose M, Lahoz Carlos, Salinero-Fort Miguel A, de Dios Olaya, Castillo Elisa, González-Alegre Teresa, García-Iglesias Francisca, Estirado Eva, Laguna Fernando, Sabín Concesa, López Silvia, Cornejo Victor, de Burgos Carmen, Sanchez Vanesa, Garcés Carmen

Abstract excerpt

BACKGROUND: The R46L variant of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has been related to lipid levels and cardiovascular disease. OBJECTIVE: To evaluate the influence of this polymorphism on subclinical vascular disease and erectile dysfunction (ED). METHODS: We analyzed the association of the PCSK9 rs11591147 single-nucleotide polymorphism with lipid levels, intima-media thickness...

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Identifiers

PMID: 29773421
DOI: 10.1016/j.jacl.2018.04.004

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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