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Article

PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses.

Journal of the American College of Cardiology - 22 Jun 2010

Benn Marianne, Nordestgaard Børge G, Grande Peer, Schnohr Peter, Tybjaerg-Hansen Anne

Abstract excerpt

OBJECTIVES: The aim of this study was to examine the effect of PCSK9 R46L on low-density lipoprotein cholesterol (LDL-C), risk of ischemic heart disease (IHD), and mortality. BACKGROUND: The 46L allele has been associated with reductions in LDL-C and risk of IHD, but results vary between studies. METHODS: We determined the association of R46L genotype with LDL-C, risk of IHD, myocardial infarction (MI), and...

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Source

Identifiers

PMID: 20579540
DOI: 10.1016/j.jacc.2010.02.044

Genes

PCSK9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses.PMID 20579540Read ↗

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