Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report.

doi:10.1161/ATVBAHA.116.307995

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Article

Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2017

Verbeek Rutger, Boyer Marjorie, Boekholdt S Matthijs, Hovingh G Kees, Kastelein John J P, Wareham Nicholas, Khaw Kay-Tee, Arsenault Benoit J

Abstract excerpt

OBJECTIVE: Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS: Lipoprotein size and composition were measured by nuclear magnetic resonance...

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Identifiers

PMID: 27856457
DOI: 10.1161/ATVBAHA.116.307995
PMCID: PMC6284798

Genes

PCSK9

Variants

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