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Article

PCSK9 R46L, Lower LDL, and Cardiovascular Disease Risk in Familial Hypercholesterolemia

3 Oct 2014

Abstract excerpt

OBJECTIVE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a downregulator of the low density lipoprotein receptor. The aims of this cross-sectional cohort-study were to examine whether the PCSK9 R46L loss of function variant found in a cohort of familial hypercholesterolemia (FH) patients was associated with lower low density lipoprotein cholesterol, lower frequency of xanthomata, and cardiovascular...

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PMID: 25278291
DOI: 10.1161/atvbaha.114.304406

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PCSK9 R46L, Lower LDL, and Cardiovascular Disease Risk in Familial HypercholesterolemiaPMID 25278291Read ↗

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